Mercedes-Benz S-Class W221
The benchmark for executive luxury, blending advanced technology with effortless V6 refinement.
- Power
- 272 bhp
- 0–60 mph
- 6.9 s
- Top speed
- 155 mph
- Est. value
- $4k–$13k
About the Mercedes-Benz S-Class W221
The W221 generation Mercedes-Benz S-Class marked a return to substantial build quality and bold styling, featuring distinctive flared wheel arches and a tech-forward interior. The S350 served as the entry-level petrol variant in many markets, powered by the smooth M272 V6 engine paired with the 7G-TRONIC transmission. It introduced pioneering safety features like the Pre-Safe system and Night View Assist, solidifying its reputation as a global leader in the luxury segment. For collectors, the W221 is appreciated for its superior ride comfort provided by the standard Airmatic suspension and its significantly improved reliability over its W220 predecessor.
Mercedes-Benz S-Class W221 specs
The Mercedes-Benz S-Class W221 produces 272 bhp (203 kW) and 350 Nm (258 lb-ft) of torque. It reaches 60 mph in 6.9 seconds and has a top speed of 155 mph (250 km/h).
| Make | Mercedes-Benz |
|---|---|
| Model | S-Class |
| Generation | W221 |
| Trim | S350 |
| Years | 2005–2013 |
| Type | Luxury |
| Body style | Saloon |
| Country | Germany |
| Engine | 3.5-litre V6 |
|---|---|
| Displacement | 3,498 cc (3.5 litres) |
| Induction | Naturally aspirated |
| Power | 272 bhp (203 kW) at 6,000 rpm |
| Torque | 350 Nm (258 lb-ft) |
| Redline | 6,500 rpm |
| 0–60 mph | 6.9 s |
| Top speed | 155 mph (250 km/h) |
| Transmission | 7-speed automatic |
| Drivetrain | Rear-wheel drive |
| Weight | 1,880 kg (4,145 lb) |
| Power-to-weight | 145 bhp per tonne |
Typical figures for the standard car; options, markets and model years vary. Where our specs come from
How much is a Mercedes-Benz S-Class W221 worth?
A typical Mercedes-Benz S-Class W221 is estimated to be worth $4,000 – $13,000 (about £3,000 – £9,700).
Values are directional estimates for a typical example, not appraisals. Condition, mileage, history and specification all change what a real car is worth. Pound figures use the exchange rate of 3 November 2026. How values are estimated
Mercedes-Benz S-Class W221 rarity in CarSpot
The Mercedes-Benz S-Class W221 is a Common card in CarSpot, with a rarity score of 7 out of 100. Everyday cars you can spot on almost any street. A Common card is worth 10 XP.
Each model's tier starts from a 0–100 score based on its value plus its power or production numbers. Once enough players have spotted a model, how often it is spotted can move it up or down one tier. How CarSpot rarity works
Rarity is a collectible game mechanic, not an assessment of real-world scarcity or value.
Mercedes-Benz S-Class W221 fun facts
- The W221 was the first Mercedes-Benz to feature the updated COMAND system with a rotary controller, a design element that became a staple across the entire range.
- Despite being the 'entry' petrol model, the S350 still achieved an electronically limited top speed of 155 mph (250 km/h).
- The W221's exterior design was overseen by Gorden Wagener and was heavily influenced by the ultra-luxury Maybach 57 and 62 saloons.
